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KMID : 1101420170490030214
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Korean Journal of Clinical Laboratory Science
2017 Volume.49 No. 3 p.214 ~ p.219
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The Serum Levels of LD and CRP in Patients of Coal Workers’ Pneumoconiosis with Chronic Obstructive Pulmonary Disease
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Lee Jong-Seong
Shin Jae-Hoon
Lee You-Lim
Baek Jin-Ee
Choi Byung-Soon
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Abstract
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Coal workers’pneumoconiosis (CWP) and chronic obstructive pulmonary disease (COPD) are characterized as chronic inflammation of the lung in miners exposed to coal mine dust. The aim of the present study was to compare the levels of serum lactate dehydrogenase (LD) and C-reactive protein (CRP) as the inflammatory indices between subjects with CWP and those with CWP and COPD (CWP+COPD), among a total of 97 subjects (27 control, 40 CWP, and 30 CWP+COPD patients). The mean levels of serum LD (165.7 vs 184.6 U/L, p=0.016) and CRP (0.08 vs 0.15 mg/dL, p=0.002) in subjects with CWP were higher than those of in subjects without CWP. The mean level of serum CRP (0.10 vs 0.19 mg/dL, p=0.008) in subjects with COPD was higher than that in subjects without COPD. In an analysis of covariance adjusted by age, the mean level of serum CRP showed statistical significance among the study groups, control, CWP, and CWP+COPD (0.07 vs 0.13 vs 0.19 mg/dL, p=0.005); the mean level of serum CRP in the CWP+COPD group was significantly higher than that of the control group (p=0.001). The results suggest that a high level of CRP in the serum may be associated with CWP and COPD in retired coal miners.
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KEYWORD
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Coal workers’ pneumoconiosis, Chronic obstructive pulmonary disease, Lactate dehydrogenase, C-reactive protein
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